NAD⁺ & Sirtuins
An NAD⁺-degrading ectoenzyme that rises with age and inflammation, draining the NAD⁺ pool.
CD38 expression climbs with inflammaging and is a major consumer of NAD⁺ — so lowering CD38 activity is a complementary strategy to adding precursors. Several flavonoids (apigenin, quercetin) are studied as CD38 inhibitors.