The Longevity OS
Evidence-based longevity,
without the hype.
A free, PubMed-backed system for longevity decisions: how the evidence is graded, what the 12 Hallmarks of Aging are, and which trial sits under each compound — before you buy or build a stack.
The molecule · rendered live
It starts smaller
than you can picture.
Trans-resveratrol — studied for sirtuin activation and healthy-aging pathways. Turn it over, zoom in. This is the actual shape doing the work, rendered live in your browser.
Rendered live
Resveratrol · 3D structure
Read this as text
Trans-resveratrol, C₁₄H₁₂O₃ — a stilbenoid polyphenol of 228.24 g/mol with a half-life near 9 hours, studied as a SIRT1 activator and graded Tier B on human evidence. Two carbon rings joined by a trans double bond, with three hydroxyl groups placed for the hydrogen bonds that hold it in the binding site. Atoms are coloured by element: C (Carbon), O (Oxygen). Stylised for legibility — not a crystallographic reproduction.
Rendered live · stylized for legibility, not a crystallographic reproduction
01 / System · Your stack, alive
Nothing works alone.
Every graded compound, plotted against the ones it boosts and the ones it clashes with. Turn the network over — the cool links are synergies, the amber ones are clashes, and the gold halos mark the TNiC elite picks. This is your stack as one connected system.
16 compounds · 23 graded links
Compound synergy network
Read this as text
16 graded compounds and 23 documented links. Link colour encodes confidence in the pairing — established, mechanistic, exploratory, caution — and a gold halo marks a TNiC elite pick.
- Elite pick · NMN
- Elite pick · Ca-AKG
- Elite pick · Resveratrol
- Elite pick · Pterostilbene
- Elite pick · Spermidine
- Elite pick · Sulforaphane
- Elite pick · GlyNAC
- Elite pick · R-ALA
Rendered live · 8 elite picks haloed gold · synergies cool, clashes amber
02 / Goal · The honest dream
Not longer. Well, longer.
Longevity's real goal isn't just more years — it's keeping function high and pushing the decline into the very end. Drag through a life to watch the two paths separate. Toggle the elite protocol to see the ceiling a graded stack aims at.
Illustrative curves — the shape of the goal, not a number promised on any bottle. The gold area is the difference between fading early and staying well to the end. The cyan ceiling is what a graded stack aims at — no supplement is proven to land you there.
The path from here
You've seen the shape.
Now build to it.
Everything below this section is the working version of what you just watched — the elite interventions graded by human evidence, the full library of 100 compounds, and a NICO Starter Questionnaire that turns it into a stack pointed at your goals.
Live instruments
Diligence-grade readouts, from day one
Educational bio-age gauge + Elite 8 modeled LQ ranking — same derived scores used on /elite-8. Not clinical predictions.
100 compounds · 12 hallmarks · 8 elite
Biological age
—
Chrono 42
Elite 8 · modeled LQ
All eight, by published dimension weights — educational ranking
- Metformin78/100AMPK ActivatorRank 1: Metformin HCl, modeled LQ 78 out of 100.
- GlyNAC77/100Glutathione PrecursorRank 2: Glycine + N-Acetylcysteine, modeled LQ 77 out of 100.
- Taurine77/100Sulfonic Amino AcidRank 3: Taurine, modeled LQ 77 out of 100.
- Rapamycin76/100mTOR InhibitorRank 4: Rapamycin (Sirolimus), modeled LQ 76 out of 100.
- NMN75/100NAD+ PrecursorRank 5: Nicotinamide Mononucleotide, modeled LQ 75 out of 100.
- Spermidine75/100Autophagy InducerRank 6: Spermidine, modeled LQ 75 out of 100.
- D+Q73/100Senolytic ComboRank 7: Dasatinib + Quercetin, modeled LQ 73 out of 100.
- Pterostilbene73/100SIRT1 ActivatorRank 8: Pterostilbene (Resveratrol analog), modeled LQ 73 out of 100.
By the numbers
The evidence base behind every grade
A live census of the published model — compounds, hallmarks, pathways and citations, counted from the registries themselves rather than typed in. Every grade traces to the strength of human evidence, tiered A–C. One verified product per compound — no pay-for-placement. How we grade.
03 / Interventions
The compounds with the strongest human evidence — and where to buy them well.
8 nutrients that act on the hallmarks of aging, each graded by the strength of human trials (4 at Tier A), paired with one verified product that matches the dose and form used in the studies. Filter by hallmark, or open any card for the full evidence.
Selections led by human clinical evidence.
Products aligned to the studied form and amount.
Manufacturer link, evidence trace, and COA guidance.
Evidence-led shortlist
Filter by the biological system you want to explore.
8 elite interventions
Glutathione Synthesis
GlyNAC
Rebuilds the glutathione antioxidant system
- Human studies cited
- 2
- Studied dose
- 600mg glycine + 600mg NAC
Verified pick
Nutri — GlyNAC-ET 1800/375mg Extra Strength
NAD+ Restoration
NMN
Restores NAD⁺ that powers sirtuins and DNA repair
- Human studies cited
- 3
- Studied dose
- 250–500mg NMN
Verified pick
Codeage Amen — NMN Nicotinamide Mononucleotide 500mg
TCA Cycle Support
Ca-AKG
Feeds the TCA cycle and α-ketoglutarate signalling
- Human studies cited
- 2
- Studied dose
- 1–2g Ca-AKG
NRF2 Activation
Sulforaphane
Switches on the NRF2 cellular-defense response
- Human studies cited
- 2
- Studied dose
- 10–35mg glucoraphanin
Verified pick
Allergy Research Group — Nrf2 Renew®
Sirtuin Activation
Trans-Resveratrol
Activates SIRT1, a caloric-restriction mimic
- Human studies cited
- 3
- Studied dose
- 150–500mg trans-resveratrol
Autophagy Induction
Spermidine
Induces autophagy — the cell’s self-cleanup pathway
- Human studies cited
- 2
- Studied dose
- 1–6mg spermidine (supplement) or dietary wheat germ
Verified pick
Oxford Healthspan — Primeadine® Original
Osmolyte / Mitochondrial Buffer
Taurine
A mitochondrial osmolyte that declines with age
- Human studies cited
- 1
- Studied dose
- 1–3g taurine daily
Redox Cycling
R-Alpha Lipoic Acid
Recycles antioxidants across water and lipid compartments
- Human studies cited
- 1
- Studied dose
- 300–600mg R-ALA
Verified pick
GeroNova — Bio-Enhanced R-Lipoic Acid 300mg
How to read this. TNiC doesn't sell or stock supplements. Picks link to the manufacturer and may carry an affiliate token — at no extra cost to you, and commission never influences which products are listed or their evidence tier. This is educational information, not medical advice; talk to a clinician before starting anything, and always request a Certificate of Analysis before you buy.
04 / Mechanisms
Twelve mechanisms of aging. A ranked, cited intervention for each.
Every hallmark links to its highest-evidence levers — compounds, lifestyle changes, and clinical options — ranked by impact and traced to PubMed, not marketing copy.
05 / Protocol
From curious to confident — no account needed.
No sign-up, no upsell, no data leaving your device — just a clear path from the science to a decision you can stand behind.
06 / Personalize
Your first move — computed for you.
Three short steps — who you are, how you're actually doing, and anything NICO needs to avoid. It then assembles an evidence-graded starting stack from the graded compound library. Nothing is stored; everything runs on your device.
- You
- Signals
- Safety
Step 1 of 3 — the basics that set your baseline.
- Free forever
- Data stays on your device
- No account needed