Not a pile of pills — a set of curated, evidence-based protocols where each compound has a job and a time. Every stack targets a specific system, layers compounds that cover each other's gaps, and links to the evidence behind every choice.
Every stack shows what each compound does, when to take it, and which hallmarks of aging it targets. Start with one that matches your goal, tap any compound to read its evidence, and talk to a clinician before you begin.
Three layers of antioxidant defense working as one system
The body's master antioxidant switch (NRF2) needs three things to fire well: raw material, a signal to turn it on, and a way to keep recycling it. GlyNAC supplies the glutathione substrate, sulforaphane flips the NRF2 switch to build the enzymes, and R-ALA regenerates the whole redox cycle. Together they cover a gap any one of them leaves open — the foundational TNiC defense stack.
Rebuild mitochondrial energy, quality control, and biogenesis together
Mitochondrial aging is three problems at once — falling fuel, weak recycling, and slow rebuilding — so fixing one leg leaves the wheel wobbling. NMN restores the NAD⁺ that powers repair, Ca-AKG feeds the TCA cycle and epigenetic cofactors, and resveratrol drives SIRT1 → PGC-1α to actually build new mitochondria. The highest hallmark coverage in the OTC catalog.
Fuel the longevity enzyme and switch it on — the classic pairing
SIRT1 is a caloric-restriction-mimicking enzyme, but it is useless without its cosubstrate. NMN supplies the NAD⁺ that fuels it while resveratrol activates it directly — cofactor plus activator. The simplest, most-studied entry point into sirtuin-driven mitochondrial and epigenetic support.
Lower blood pressure and keep arteries young from four directions
Vascular aging is where a huge share of healthspan is won or lost, and these four hit it through independent routes: cocoa flavanols and beetroot both raise nitric oxide (from two different pathways), aged garlic lowers blood pressure and slows plaque, and omega-3 resolves the inflammation underneath. Each has real human outcome data — stacked, they cover more of the vascular picture than any single one.
Clear the "zombie" senescent cells that drive inflammaging
Senescent cells stop dividing but refuse to die, pumping out inflammatory signals that age the tissue around them. Senolytics clear them — and the evidence-based way to use them is a short, high-dose pulse a couple of days a month, not daily. Fisetin has the highest senolytic potency of the dietary flavonoids, and quercetin is the founding partner of the senolytic approach.
This stack works on two timescales. Citicoline and L-theanine give an immediate, clean lift in attention — choline for acetylcholine and membranes, theanine for calm, jitter-free focus — while lion’s mane plays the long game, stimulating nerve growth factor to support neuronal health as you age. Fast payoff plus a structural investment.
Glucose control and a better lipid panel, without a prescription
Two of the strongest non-prescription metabolic levers, hitting complementary targets. Berberine activates AMPK with glucose control that went head-to-head with metformin in an RCT; bergamot works the cholesterol side through the same pathway statins target, dropping LDL and triglycerides. Together they cover glucose and lipids — the metabolic core of healthspan.
Protect the mitochondria you have and help build new ones
A protect-plus-build approach to mitochondrial aging. MitoQ delivers antioxidant defense concentrated *inside* the mitochondria (where generic CoQ10 struggles to reach), CoQ10 supports the electron-transport chain across the cell — essential if you take a statin — and PQQ nudges the PGC-1α biogenesis program that grows new mitochondria. Defense at the source, plus renewal.
Want a stack tuned to your own goals, biomarkers, and safety profile? The Stack Architect builds one for you — with synergy scoring and contraindication checks.