EVIDENCE-BASED · MODELED RANKING

The Elite 8

Eight premier longevity interventions ranked by the Longevity Quotient — a calibrated synthesis of clinical rigor, epigenetic signals, evolutionary conservation, and safety.

For research & educational use only · Not medical advice

Leaderboard snapshot

Default Longevity Quotient weights

The Longevity Quotient equation

LQ(p) = 0.22·CE + 0.18·EB + 0.16·ES + 0.14·EE + 0.12·SF + 0.10·BV + 0.05·HP − 0.03·R

CE (22%) — RCT quality, meta-analyses, N-size

EB (18%) — Methylation clock improvements

ES (16%) — Magnitude of benefit (Cohen's d equiv)

EE (14%) — Conserved pathway target across species

SF (12%) — Tolerability, adverse event rate

BV (10%) — Absorption, delivery, formulation quality

HP (5%) — Observational cohort / epidemiological signal

R (3%) — Adverse events, drug interactions (subtracted) [subtracted]

Dimension scores (0–10) are editorially synthesized from peer-reviewed literature. Weights reflect TNiC's evidence hierarchy — not a peer-reviewed meta-score. LQ rankings are modeled synthesis, not clinical recommendations. See evidence tier grading for study-level analysis.

Scores synthesized from peer-reviewed literature. This tool is for educational and research purposes only. Rx compounds require physician oversight. Part of the TNiC Trust Center.