EVIDENCE-BASED · MODELED RANKING

The Elite 8

Eight premier longevity interventions ranked by the Longevity Quotient — a calibrated synthesis of clinical rigor, epigenetic signals, evolutionary conservation, and safety.

For research & educational use only · Not medical advice

Leaderboard snapshot

Default Longevity Quotient weights

The Longevity Quotient equation

LQ(p) = 0.22·CE + 0.18·EB + 0.16·ES + 0.14·EE + 0.12·SF + 0.10·BV + 0.05·HP − 0.03·R

CE (22%) — RCT quality, meta-analyses, N-size

EB (18%) — Methylation clock improvements

ES (16%) — Magnitude of benefit (Cohen's d equiv)

EE (14%) — Conserved pathway target across species

SF (12%) — Tolerability, adverse event rate

BV (10%) — Absorption, delivery, formulation quality

HP (5%) — Observational cohort / epidemiological signal

R (3%) — Adverse events, drug interactions [subtracted]

Dimension scores (0–10) are editorially synthesized from peer-reviewed literature. Weights reflect TNiC's evidence hierarchy — not a peer-reviewed meta-score. LQ rankings are modeled synthesis, not clinical recommendations. See evidence tier grading for study-level analysis.

Scores synthesized from peer-reviewed literature. This tool is for educational and research purposes only. Rx compounds require physician oversight. Part of the TNiC Trust Center.

Continue

After the Elite shortlist.

Explore

Explore the library

Full evidence modules for every ranked compound.

Decide

Build in Stack Architect

Load Elite picks and check interactions.

Verify

Verify stack

Dose-matched buyer checklists.

Start

Start with NICO

Personalize beyond the global shortlist.

Explore the evidence

Where to go from here.

The compound libraryEvery graded compound, by hallmark The evidence tableAll of it as one sortable index PathwaysThe mechanisms compounds act through 12 HallmarksMechanism maps with PMID-cited interventions Peptide libraryEvidence tier and legal status, stated plainly Evidence comparisonsHead-to-head tables with PMID anchors InsightsEditorial deep-dives on longevity questions Best by goalGoal-led shortlists, without hype How this is gradedWhat Tier A, B and C each require

Decide & build

Turn evidence into a stack you can inspect.

Stack ArchitectPresets, synergy scoring, and shareable stack URLs Protocol libraryChoreographed stacks where each compound has a job Longevity toolsSimulator, protocol engine, forecasts — rule-based Start with NICOPersonalized starter stack from your answers Compound EngineScore evidence, effect, breadth, and safety Combination LabMarginal contribution and explainable stack scoring Biological ageEducational bio-age gauge from lifestyle inputs

Verify & track

Confirm the buy, log the labs, keep the trail honest.

Verify stackCOA checklists filtered by your active stack Verified productsOne dose-matched pick per graded compound Lab HubLog biomarkers locally — supplements without labs is guessing Trust & transparencyHow grades, citations, and sponsorship are held accountable Grading methodologyTier criteria you can audit My Longevity OSTrack stack status, labs, and next steps Protocol BriefPMID digest mapped to modules and stacks