The mechanistic layer between what you take and what ages — the pathways (PINK1/Parkin, SIRT3, NRF2, AMPK, mTOR, NAD⁺ …) that compounds engage. Each pathway links to the hallmarks it acts on and every compound that targets it.
19 pathways across 5 families.
The NAD⁺-dependent deacetylases and repair enzymes that translate energy status into DNA repair, mitophagy, and epigenetic maintenance.
The central redox and signaling coenzyme every sirtuin and PARP depends on — and it falls ~50% between ages 40 and 60.
4 compounds · 5 hallmarks
The NAD⁺-dependent deacetylase that couples energy status to epigenetic maintenance, autophagy, and inflammatory restraint.
4 compounds · 5 hallmarks
The mitochondrial sirtuin that deacetylates metabolic enzymes and enables mitochondrial quality control.
3 compounds · 2 hallmarks
The chromatin sirtuin governing DNA double-strand-break repair, telomere maintenance, and genome stability.
2 compounds · 3 hallmarks
DNA-damage sensors that repair strand breaks by consuming large amounts of NAD⁺.
2 compounds · 1 hallmark
An NAD⁺-degrading ectoenzyme that rises with age and inflammation, draining the NAD⁺ pool.
3 compounds · 2 hallmarks
The growth-vs-repair switches — mTOR, AMPK, FOXO — that decide whether a cell builds or maintains.
The master growth kinase — when active it builds; when inhibited, cells shift to repair and autophagy.
3 compounds · 4 hallmarks
The cellular low-energy sensor that switches on fat burning, mitochondrial biogenesis, and autophagy.
4 compounds · 3 hallmarks
A longevity-associated transcription factor that turns on stress-resistance, antioxidant, and repair genes.
3 compounds · 3 hallmarks
Mitophagy and biogenesis pathways that clear damaged mitochondria and build new ones.
The sensor–tag pair that marks damaged mitochondria for selective recycling (mitophagy).
2 compounds · 2 hallmarks
The master regulator of mitochondrial biogenesis — the making of new mitochondria.
3 compounds · 1 hallmark
The transcription factor that switches on the autophagy–lysosome clearance program.
2 compounds · 2 hallmarks
The kinase that initiates autophagosome formation — the first committed step of autophagy.
2 compounds · 1 hallmark
The antioxidant and inflammatory master switches — NRF2, NF-κB, the inflammasome — that set redox and inflammatory tone.
The master antioxidant switch that turns on 200+ cytoprotective and detoxification genes.
6 compounds · 3 hallmarks
The central pro-inflammatory transcription factor whose chronic activation drives inflammaging.
6 compounds · 3 hallmarks
The innate-immune sensor complex that releases IL-1β and IL-18 — a key inflammaging amplifier.
3 compounds · 2 hallmarks
The body's most abundant endogenous antioxidant — depleted ~10–15% per decade after age 20.
5 compounds · 3 hallmarks
Vascular, neuronal, and proteostasis signaling nodes that compounds act through.