NAD⁺ & Sirtuins
The NAD⁺-dependent deacetylase that couples energy status to epigenetic maintenance, autophagy, and inflammatory restraint.
SIRT1 deacetylates histones and metabolic regulators (PGC-1α, FOXO, NF-κB), linking a healthy NAD⁺ pool to slower epigenetic drift and calmer inflammaging. It is the node resveratrol and pterostilbene are best known for activating.