NAD⁺ & Sirtuins
The mitochondrial sirtuin that deacetylates metabolic enzymes and enables mitochondrial quality control.
SIRT3 tunes the mitochondrial acetylome — activating SOD2 antioxidant defense and enzymes of fat oxidation and the TCA cycle. Because it runs on NAD⁺, restoring NAD⁺ is the primary lever on SIRT3 activity.