NAD⁺ & Sirtuins

SIRT3

The mitochondrial sirtuin that deacetylates metabolic enzymes and enables mitochondrial quality control.

Role in aging

SIRT3 tunes the mitochondrial acetylome — activating SOD2 antioxidant defense and enzymes of fat oxidation and the TCA cycle. Because it runs on NAD⁺, restoring NAD⁺ is the primary lever on SIRT3 activity.

Hallmarks it acts on

6Mitochondrial Dysfunction
1Genomic Instability

Compounds that engage it

NMN (Nicotinamide Mononucleotide)
NR (Nicotinamide Riboside)
Ca-AKG (Calcium Alpha-Ketoglutarate)

See how the library connects All pathways