NAD⁺ & Sirtuins

PARP1/2

DNA-damage sensors that repair strand breaks by consuming large amounts of NAD⁺.

Role in aging

When DNA damage accumulates, PARP1/2 activation burns through the NAD⁺ pool to drive repair — competing with sirtuins for the same fuel. This is why genomic instability and NAD⁺ decline reinforce each other with age.

Hallmarks it acts on

1Genomic Instability

Compounds that engage it

NMN (Nicotinamide Mononucleotide)
NR (Nicotinamide Riboside)

See how the library connects All pathways