Mitochondrial Quality

PINK1/Parkin

The sensor–tag pair that marks damaged mitochondria for selective recycling (mitophagy).

Role in aging

PINK1 accumulates on depolarized (damaged) mitochondria and recruits Parkin to tag them for autophagic clearance. Failing mitophagy lets dysfunctional mitochondria accumulate, leaking ROS and driving inflammaging — the gap urolithin A is studied to address.

Hallmarks it acts on

6Mitochondrial Dysfunction
5Disabled Macroautophagy

Compounds that engage it

Urolithin A
Spermidine

See how the library connects All pathways