NAD⁺ & Sirtuins

SIRT6

The chromatin sirtuin governing DNA double-strand-break repair, telomere maintenance, and genome stability.

Role in aging

SIRT6 stabilizes telomeric chromatin and promotes double-strand-break repair; its decline links genomic instability to telomere attrition. Like all sirtuins it is NAD⁺-dependent.

Hallmarks it acts on

1Genomic Instability
2Telomere Attrition
3Epigenetic Alterations

Compounds that engage it

NMN (Nicotinamide Mononucleotide)
NR (Nicotinamide Riboside)

See how the library connects All pathways