Cellular Defense

NLRP3 inflammasome

The innate-immune sensor complex that releases IL-1β and IL-18 — a key inflammaging amplifier.

Role in aging

The NLRP3 inflammasome converts cellular stress signals (including from senescent cells and damaged mitochondria) into potent inflammatory cytokines. Suppressing it is a targeted way to lower the inflammatory tone that accelerates most hallmarks.

Hallmarks it acts on

10Chronic Inflammation
7Cellular Senescence

Compounds that engage it

Sulforaphane
Omega-3 (EPA + DHA)
Luteolin

See how the library connects All pathways