Nutrient Sensing

FOXO3

A longevity-associated transcription factor that turns on stress-resistance, antioxidant, and repair genes.

Role in aging

FOXO3 (one of the few genes consistently linked to human longevity) is activated downstream of AMPK and sirtuins to upregulate antioxidant defense, autophagy, and DNA repair — a broad "maintenance program" transcription factor.

Hallmarks it acts on

4Loss of Proteostasis
1Genomic Instability
7Cellular Senescence

Compounds that engage it

Trans-Resveratrol
Berberine HCl
Spermidine

See how the library connects All pathways