Cellular Defense
The master antioxidant switch that turns on 200+ cytoprotective and detoxification genes.
Held inactive by KEAP1 until a mild oxidative signal releases it, NRF2 then upregulates glutathione synthesis, NQO1, HO-1, and the wider antioxidant network. It is the hormetic target behind sulforaphane and the "activate your own defenses" strategy.