The Evidence Table
Every grade, side by side.
The whole library as one table — tier, composite score, score confidence and hallmark coverage for all 100 graded compounds. Sort it, filter it, and see exactly where the evidence thins out.
Evidence split
100graded
- A · Clinical1010%
- B · Emerging7171%
- C · Preclinical1919%
80 scored · 20 not scored
Open the table →Evidence split · derived from the graded library
Library · Evidence Tools
The Evidence Table
Every compound TNiC has graded, in one view, with the same tier and score its own deep-dive carries. Nothing here is authored separately — each row reads from the registry behind that compound's page, including where that registry has nothing to say.
Read this before the numbers
The tier is the claim TNiC stands behind: A, B or C, set by the strength of human evidence. TNiC Score is a derived convenience — a composite across six dimensions — and it is only as good as the source under it. Of the 100 compounds here, 80 can be scored at all; of those, 5 at high confidence, 19 at moderate, and 57 at limited. The remaining 20 have no scored source and are listed as Not scored rather than given a number to fill the column. Sort by score if it is useful, but the tier is the grade. How the grading works
All 100 graded compounds
Showing 100 of 100 graded compounds
| Compound | Tier | TNiC Score | Confidence | Hallmarks |
|---|---|---|---|---|
| Creatine MonohydratePhosphocreatine ATP buffer — Tier A for muscle and strength in aging | Tier AClinical | 84/100 | Moderate | Mitochondrial DysfunctionStem Cell ExhaustionDeregulated Nutrient Sensing |
| Omega-3 (EPA + DHA)REDUCE-IT: 25% CV event reduction — SPM resolution axis | Tier AClinical | 82/100 | Moderate | Chronic InflammationAltered Intercellular CommunicationTelomere AttritionDysbiosis |
| Berberine HClAMPK activator — metformin-equivalent glucose outcomes without a prescription | Tier AClinical | 79/100 | Moderate | Deregulated Nutrient SensingChronic InflammationMitochondrial DysfunctionAltered Intercellular Communication |
| GlyNAC (Glycine + NAC)Flagship glutathione restoration — human RCT backbone | Tier AClinical | 77/100 | High | Mitochondrial DysfunctionLoss of ProteostasisChronic InflammationGenomic Instability |
| NMN (Nicotinamide Mononucleotide)NAD+ precursor — sirtuin and PARP fuel | Tier AClinical | 75/100 | High | Mitochondrial DysfunctionGenomic InstabilityEpigenetic AlterationsCellular SenescenceDeregulated Nutrient Sensing |
| SulforaphaneNRF2 master regulator — 200+ cytoprotective genes | Tier AClinical | 73/100 | Moderate | Genomic InstabilityChronic InflammationLoss of Proteostasis |
| Ca-AKG (Calcium Alpha-Ketoglutarate)Epigenetic cofactor & TCA fuel — highest hallmark breadth per gram | Tier AClinical | 72/100 | Moderate | Epigenetic AlterationsMitochondrial DysfunctionStem Cell Exhaustion |
| Urolithin AMitophagy activator — Phase 2 muscle trial, Tier A | Tier AClinical | 72/100 | Moderate | Mitochondrial DysfunctionDisabled MacroautophagyCellular Senescence |
| IodineEssential thyroid substrate — deficiency is quietly returning as iodized salt use falls | Tier AClinical | 71/100 | Limited | Altered Intercellular CommunicationDeregulated Nutrient Sensing |
| NR (Nicotinamide Riboside)NAD+ precursor alternative — human RCT data, manual stack substitution | Tier AClinical | Not scored | — | Mitochondrial DysfunctionGenomic InstabilityEpigenetic AlterationsCellular SenescenceDeregulated Nutrient Sensing |
| Magnesium (Glycinate / Threonate)Essential ATP-Mg2+ cofactor — modest, repletion-shaped RCT wins for BP, insulin sensitivity, and sleep | Tier BEmerging | 79/100 | Moderate | Genomic InstabilityMitochondrial DysfunctionDeregulated Nutrient Sensing |
| TaurineAge-depleted osmolyte — Science 2023 lifespan signals | Tier BEmerging | 77/100 | High | Mitochondrial DysfunctionChronic InflammationGenomic Instability |
| GlycineConditionally-essential amino acid: glutathione substrate, methyl-group buffer, and NMDA-mediated sleep aid — small but real human RCTs, preclinical lifespan signal. | Tier BEmerging | 76/100 | Moderate | Loss of ProteostasisMitochondrial DysfunctionDeregulated Nutrient Sensing |
| TMG (Trimethylglycine / Betaine)BHMT methyl donation — evidence-graded deep dive | Tier BEmerging | 76/100 | Moderate | Epigenetic AlterationsAltered Intercellular Communication |
| N-Acetylcysteine (NAC)Cysteine donor that refills glutathione — strong mechanism and safety, thin standalone longevity data (Tier B). | Tier BEmerging | 75/100 | Moderate | Loss of ProteostasisChronic InflammationMitochondrial Dysfunction |
| SpermidineAutophagy polyamine — Madeo 2021 memory RCT | Tier BEmerging | 75/100 | High | Disabled MacroautophagyEpigenetic AlterationsCellular Senescence |
| CoQ10 (Ubiquinol)Electron transport chain cofactor — essential for statin users | Tier BEmerging | 74/100 | Moderate | Mitochondrial DysfunctionChronic InflammationGenomic Instability |
| PterostilbeneMethylated resveratrol — 4× bioavailability | Tier BEmerging | 73/100 | High | Mitochondrial DysfunctionEpigenetic AlterationsChronic Inflammation |
| R-Alpha Lipoic Acid (R-ALA)Mitochondrial redox recycler — NRF2 stack completion | Tier BEmerging | 72/100 | Moderate | Mitochondrial DysfunctionLoss of ProteostasisChronic Inflammation |
| EGCG (Green Tea Catechin)AMPK and redox signaling — evidence-graded deep dive | Tier BEmerging | 69/100 | Moderate | Epigenetic AlterationsChronic InflammationMitochondrial Dysfunction |
| QuercetinFounding senolytic flavonoid — strong mechanism, early human outcomes | Tier BEmerging | 69/100 | Moderate | Cellular SenescenceChronic Inflammation |
| Curcumin (Curcuminoids)Turmeric polyphenol with Tier-A knee-OA symptom relief, Tier-B systemic inflammation effects, and a defining bioavailability problem | Tier BEmerging | 68/100 | Moderate | Chronic InflammationCellular SenescenceAltered Intercellular Communication |
| SeleniumSelenoprotein Redox Defense — evidence-graded deep dive | Tier BEmerging | 68/100 | Limited | Genomic InstabilityChronic Inflammation |
| Inulin / Prebiotic FiberMicrobiome SCFA production — evidence-graded deep dive | Tier BEmerging | 67/100 | Limited | DysbiosisChronic InflammationDeregulated Nutrient Sensing |
| Acetyl-L-Carnitine (ALCAR)Brain-penetrant carnitine — Tier B for DPN, MCI, and depression with a large evidence base | Tier BEmerging | 66/100 | Limited | Mitochondrial DysfunctionAltered Intercellular CommunicationChronic Inflammation |
| AstaxanthinMembrane antioxidant defense — evidence-graded deep dive | Tier BEmerging | 66/100 | Limited | Mitochondrial DysfunctionChronic InflammationAltered Intercellular Communication |
| Bacopa Monnieri (Brahmi)Ayurvedic nootropic — real memory consolidation at 8-12 weeks, no acute effect | Tier BEmerging | 66/100 | Limited | Altered Intercellular CommunicationLoss of ProteostasisChronic Inflammation |
| Benfotiamine (Fat-Soluble B1)Transketolase activator that blocks all four AGE-formation pathways in hyperglycemia | Tier BEmerging | 66/100 | Limited | Loss of ProteostasisChronic InflammationDeregulated Nutrient Sensing |
| Capsaicin (Cayenne / Chili)TRPV1 agonist with a 14% mortality signal in China Kadoorie and topical Tier A for neuropathic pain | Tier BEmerging | 66/100 | Limited | Deregulated Nutrient SensingChronic InflammationMitochondrial Dysfunction |
| Chondroitin SulfateCartilage glycosaminoglycan — MOVES showed non-inferiority to celecoxib for knee OA | Tier BEmerging | 66/100 | Limited | Chronic InflammationLoss of ProteostasisAltered Intercellular Communication |
| Ginkgo Biloba (EGb 761)Vascular cognition — real effect in established dementia, negative for prevention (GEM trial) | Tier BEmerging | 66/100 | Limited | Altered Intercellular CommunicationMitochondrial DysfunctionChronic Inflammation |
| HMB (β-Hydroxy β-Methylbutyrate)The strongest RCT evidence for preventing muscle loss during bed rest, hospitalization, and sarcopenia | Tier BEmerging | 66/100 | Limited | Stem Cell ExhaustionLoss of ProteostasisChronic Inflammation |
| Krill Oil (Phospholipid Omega-3)Phospholipid-bound EPA/DHA plus astaxanthin — higher bioavailability per mg than fish oil | Tier BEmerging | 66/100 | Limited | Chronic InflammationAltered Intercellular CommunicationDeregulated Nutrient Sensing |
| MCT Oil (Medium-Chain Triglycerides / C8:C10)Portal-vein absorbed fats → ketones → the Cunnane MCI cognitive brain-fuel intervention | Tier BEmerging | 66/100 | Limited | Mitochondrial DysfunctionDeregulated Nutrient SensingAltered Intercellular Communication |
| Methylcobalamin (Active B12)Direct-active B12 for age-related atrophic gastritis and methylation stacks | Tier BEmerging | 66/100 | Limited | Epigenetic AlterationsAltered Intercellular CommunicationLoss of Proteostasis |
| Milk Thistle (Silymarin / Silybin)Flavonolignan hepatoprotection — real NAFLD and diabetic-glycemic RCT evidence | Tier BEmerging | 66/100 | Limited | Chronic InflammationLoss of ProteostasisDeregulated Nutrient Sensing |
| MSM (Methylsulfonylmethane)Bioavailable sulfur for connective tissue and GSH substrate — modest knee-OA RCT signal | Tier BEmerging | 66/100 | Limited | Chronic InflammationLoss of ProteostasisGenomic Instability |
| Niacin (Nicotinic Acid, Vitamin B3)The lipid-modifying B3 form — dramatically raises HDL and lowers Lp(a), but AIM-HIGH/HPS2-THRIVE were negative | Tier BEmerging | 66/100 | Limited | Altered Intercellular CommunicationGenomic InstabilityDeregulated Nutrient Sensing |
| Panax Ginseng (Korean / Asian Ginseng)Adaptogen with real fatigue-reduction and glycemic RCTs — cycle to prevent tachyphylaxis | Tier BEmerging | 66/100 | Limited | Altered Intercellular CommunicationChronic InflammationDeregulated Nutrient Sensing |
| Phosphatidylserine (PS)Neuronal membrane phospholipid — cognitive support and the reproducible post-exercise cortisol lever | Tier BEmerging | 66/100 | Limited | Altered Intercellular CommunicationLoss of ProteostasisChronic Inflammation |
| Trigonelline (Frontier NAD+ Precursor)The 2024 NAD+ story — elevated in centenarians, restores muscle mitochondrial function in aged models | Tier BEmerging | 66/100 | Limited | Mitochondrial DysfunctionDeregulated Nutrient SensingGenomic InstabilityLoss of Proteostasis |
| Turkey Tail (Trametes versicolor, PSK / PSP)The best-evidenced medicinal mushroom — PSK is an approved oncology adjunct in Japan and China | Tier BEmerging | 66/100 | Limited | Altered Intercellular CommunicationCellular SenescenceChronic Inflammation |
| Vitamin C (Ascorbic Acid)Essential cofactor for collagen and neurotransmitter synthesis; PHS-II negative for CV prevention | Tier BEmerging | 66/100 | Limited | Loss of ProteostasisChronic InflammationAltered Intercellular Communication |
| Methylfolate (L-5-MTHF / L-Methylfolate)The MTHFR bypass — bioactive folate for methylation-dependent variants | Tier BEmerging | 65/100 | Limited | Epigenetic AlterationsAltered Intercellular CommunicationGenomic Instability |
| Vitamin D3 (Cholecalciferol)Fixing a real vitamin-D deficiency is one of the highest-yield, best-evidenced moves in the stack | Tier BEmerging | 65/100 | Limited | Chronic InflammationAltered Intercellular CommunicationGenomic Instability |
| ZincEssential trace mineral; corrects age-related immune decline in the deficient, with genuine RCT infection data and indirect longevity rationale. | Tier BEmerging | 65/100 | Limited | Chronic InflammationGenomic InstabilityAltered Intercellular Communication |
| FisetinSenolytic flavonoid — Mayo Clinic pilot, highest potency ranking | Tier BEmerging | 64/100 | Moderate | Cellular SenescenceAltered Intercellular CommunicationChronic Inflammation |
| PEA (Palmitoylethanolamide)Endogenous PPAR-α agonist — "endocannabinoid without CB1" with real meta-analytic pain evidence | Tier BEmerging | 64/100 | Limited | Chronic InflammationAltered Intercellular CommunicationLoss of Proteostasis |
| UC-II (Undenatured Type II Collagen)Native chicken-sternum collagen at 40 mg/day — oral tolerance, not substrate; beats G+C in head-to-head RCTs | Tier BEmerging | 64/100 | Limited | Chronic InflammationAltered Intercellular CommunicationLoss of Proteostasis |
| Alpha-GPC (L-Alpha-Glycerylphosphorylcholine)The choline form that reaches the brain — cholinergic support with real cognitive-decline RCTs | Tier BEmerging | 63/100 | Limited | Altered Intercellular CommunicationStem Cell Exhaustion |
| Ashwagandha (Withania somnifera)Stress-response modulation — evidence-graded deep dive | Tier BEmerging | 63/100 | Limited | Chronic InflammationAltered Intercellular Communication |
| HesperidinEndothelial flavanone signaling — evidence-graded deep dive | Tier BEmerging | 63/100 | Limited | Altered Intercellular CommunicationChronic Inflammation |
| Mucuna Pruriens (Velvet Bean, L-DOPA)Natural L-DOPA — dopaminergic support that should be treated as a real drug, not just an herb | Tier BEmerging | 63/100 | Limited | Altered Intercellular CommunicationStem Cell Exhaustion |
| P5P (Pyridoxal-5-Phosphate, Active B6)The direct-active B6 coenzyme — bypass hepatic conversion, cofactor for 150+ enzymes | Tier BEmerging | 63/100 | Limited | Epigenetic AlterationsAltered Intercellular Communication |
| Piperine (BioPerine)Black-pepper bioenhancer — 20× curcumin absorption, and a real drug-interaction concern | Tier BEmerging | 63/100 | Limited | Deregulated Nutrient SensingChronic Inflammation |
| Pumpkin Seed OilWeak 5α-reductase modulator with the GRANU BPH trial and a real male-AGA hair-count signal | Tier BEmerging | 63/100 | Limited | Altered Intercellular CommunicationChronic Inflammation |
| BromelainPineapple proteolytic enzyme — sports medicine and sinusitis workhorse, real anticoagulant potentiation | Tier BEmerging | 62/100 | Limited | Chronic InflammationAltered Intercellular Communication |
| Glucosamine SulfateLarge observational cohorts link regular use to lower mortality — associational, not causal. | Tier BEmerging | 62/100 | Limited | Chronic InflammationDeregulated Nutrient Sensing |
| L-ArginineeNOS substrate for endothelial NO — but VINTAGE-MI is a hard post-MI contraindication | Tier BEmerging | 62/100 | Limited | Altered Intercellular CommunicationChronic Inflammation |
| L-CitrullineNitric-oxide support — evidence-graded deep dive | Tier BEmerging | 62/100 | Limited | Altered Intercellular CommunicationMitochondrial Dysfunction |
| Nicotinamide (NAM)NAD precursor and DNA repair — evidence-graded deep dive | Tier BEmerging | 62/100 | Limited | Genomic InstabilityEpigenetic Alterations |
| Tocotrienols (Vitamin E)Lipid redox protection — evidence-graded deep dive | Tier BEmerging | 62/100 | Limited | Chronic InflammationMitochondrial Dysfunction |
| Trans-ResveratrolSIRT1 activator — caloric restriction mimetic | Tier BEmerging | 62/100 | Moderate | Mitochondrial DysfunctionEpigenetic AlterationsChronic InflammationCellular Senescence |
| Vitamin K2 (MK-7)The calcium-routing cofactor: activates MGP and osteocalcin, with mixed 3-year RCT outcomes | Tier BEmerging | 62/100 | Limited | Altered Intercellular CommunicationChronic Inflammation |
| Boswellia serrata (AKBA)5-LOX inflammatory signaling — evidence-graded deep dive | Tier BEmerging | 60/100 | Limited | Chronic Inflammation |
| MelatoninCircadian hormone and mitochondrial antioxidant — Tier A for sleep, Tier B/C for longevity. | Tier BEmerging | 55/100 | Limited | Mitochondrial DysfunctionChronic InflammationAltered Intercellular Communication |
| AcarbosePost-meal glucose attenuation — evidence-graded deep dive | Tier BEmerging | Not scored | — | Deregulated Nutrient SensingChronic Inflammation |
| Aged Garlic ExtractOne of the best-evidenced cardiovascular supplements — lowers blood pressure and slows coronary plaque in imaging trials | Tier BEmerging | Not scored | — | Altered Intercellular CommunicationChronic InflammationDeregulated Nutrient Sensing |
| Beetroot / Dietary NitrateA direct, food-based nitric-oxide boost — lower blood pressure and more efficient muscles, backed by consistent RCTs | Tier BEmerging | Not scored | — | Altered Intercellular CommunicationMitochondrial Dysfunction |
| Canagliflozin (SGLT2 inhibitor)Renal glucose excretion — evidence-graded deep dive | Tier BEmerging | Not scored | — | Deregulated Nutrient SensingAltered Intercellular Communication |
| Citicoline (CDP-Choline)Highly bioavailable choline for attention and memory — feeds both acetylcholine and neuronal membrane repair | Tier BEmerging | Not scored | — | Altered Intercellular Communication |
| Citrus BergamotA polyphenol lipid lever with real RCTs lowering LDL and triglycerides — statin-like pathway, no prescription | Tier BEmerging | Not scored | — | Deregulated Nutrient SensingChronic InflammationAltered Intercellular Communication |
| Cocoa FlavanolsAmong the best-studied nutrients for the aging vascular system — NO, blood pressure, and a cardiovascular-death signal in COSMOS | Tier BEmerging | Not scored | — | Altered Intercellular CommunicationChronic InflammationMitochondrial Dysfunction |
| Collagen PeptidesOne of the best-evidenced supplements for skin elasticity, joint comfort, and bone — building blocks that also signal repair | Tier BEmerging | Not scored | — | Altered Intercellular CommunicationChronic Inflammation |
| Grape Seed Extract (95% OPC)A potent OPC antioxidant with real human RCTs behind its blood-pressure and vascular support | Tier BEmerging | Not scored | — | Chronic InflammationGenomic InstabilityMitochondrial DysfunctionAltered Intercellular Communication |
| L-TheanineCalm, focused alertness without sedation — the most replicable acute nootropic, and it tames caffeine jitter | Tier BEmerging | Not scored | — | Altered Intercellular CommunicationChronic Inflammation |
| MetforminPrescription biguanide with Tier-A diabetes data and a genuinely unsettled Tier-B geroprotection case. | Tier BEmerging | Not scored | — | Deregulated Nutrient SensingMitochondrial DysfunctionChronic InflammationAltered Intercellular Communication |
| MitoQ (Mitoquinol)CoQ10 re-engineered to reach inside mitochondria — a landmark RCT restored older adults' vascular function | Tier BEmerging | Not scored | — | Mitochondrial DysfunctionAltered Intercellular Communication |
| NattokinaseA fibrinolytic enzyme from natto with human RCTs for blood pressure, clot breakdown, and arterial health | Tier BEmerging | Not scored | — | Altered Intercellular CommunicationChronic Inflammation |
| Rapamycin (Sirolimus)mTORC1 inhibition — strongest preclinical lifespan drug | Tier BEmerging | Not scored | — | Disabled MacroautophagyDeregulated Nutrient SensingCellular SenescenceMitochondrial Dysfunction |
| TUDCA (Tauroursodeoxycholic Acid)ER stress chaperone — proteostasis & mitochondrial support | Tier BEmerging | Not scored | — | Loss of ProteostasisMitochondrial DysfunctionDisabled Macroautophagy |
| PQQ (Pyrroloquinoline Quinone)PGC-1alpha Mitochondrial Signaling — evidence-graded deep dive | Tier CPreclinical | 62/100 | Moderate | Mitochondrial DysfunctionChronic Inflammation |
| ApigeninCD38 and inflammatory signaling — evidence-graded deep dive | Tier CPreclinical | 61/100 | Moderate | Chronic InflammationCellular Senescence |
| Butyrate (Sodium / Tributyrin)SCFA and HDAC signaling — evidence-graded deep dive | Tier CPreclinical | 57/100 | Limited | DysbiosisEpigenetic AlterationsChronic Inflammation |
| Astragalus (Astragalus membranaceus)The cycloastragenol / TA-65 telomere story — real, modest, and expensive | Tier CPreclinical | 56/100 | Limited | Telomere AttritionAltered Intercellular CommunicationChronic Inflammation |
| Cordyceps (Cordyceps militaris / sinensis)Medicinal mushroom with a plausible mitochondrial mechanism and one honest older-adult VO₂max RCT | Tier CPreclinical | 56/100 | Limited | Mitochondrial DysfunctionChronic InflammationAltered Intercellular Communication |
| ErgothioneineOCTN1 cytoprotective transport — evidence-graded deep dive | Tier CPreclinical | 56/100 | Limited | Mitochondrial DysfunctionChronic InflammationGenomic Instability |
| Mixed Tocopherols (Full-Spectrum Vitamin E)Preserve γ-tocopherol — SELECT and Miller meta made isolated α-tocopherol a bad bet | Tier CPreclinical | 56/100 | Limited | Chronic InflammationMitochondrial DysfunctionLoss of Proteostasis |
| Reishi (Ganoderma lucidum)"Spirit mushroom" of TCM — genuine immune mechanism, modest human evidence | Tier CPreclinical | 56/100 | Limited | Altered Intercellular CommunicationChronic InflammationDeregulated Nutrient Sensing |
| Superoxide Dismutase (SOD, Oral GliSODin)Melon-derived SOD with gliadin coating — an Nrf2 signaling dose, not an enzyme-replacement supplement | Tier CPreclinical | 56/100 | Limited | Mitochondrial DysfunctionChronic InflammationGenomic Instability |
| Gynostemma pentaphyllum (Jiaogulan)AMPK-linked metabolic signaling — evidence-graded deep dive | Tier CPreclinical | 54/100 | Limited | Deregulated Nutrient SensingMitochondrial Dysfunction |
| Hyaluronic Acid (Oral)Extracellular-matrix hydration — evidence-graded deep dive | Tier CPreclinical | 54/100 | Limited | Altered Intercellular CommunicationChronic Inflammation |
| L-CarnosineCarbonyl and glycation defense — evidence-graded deep dive | Tier CPreclinical | 54/100 | Limited | Loss of ProteostasisCellular Senescence |
| LuteolinNeuroinflammatory signaling — evidence-graded deep dive | Tier CPreclinical | 53/100 | Limited | Cellular SenescenceChronic Inflammation |
| Rhodiola roseaStress and fatigue signaling — evidence-graded deep dive | Tier CPreclinical | 53/100 | Limited | Mitochondrial DysfunctionChronic Inflammation |
| TheobromineCocoa's cardiovascular fraction — vasodilator, cough suppressant, and 7-hour half-life | Tier CPreclinical | 53/100 | Limited | Altered Intercellular CommunicationChronic Inflammation |
| 17-alpha-EstradiolSex-specific metabolic signaling — evidence-graded deep dive | Tier CPreclinical | Not scored | — | Deregulated Nutrient SensingChronic Inflammation |
| DasatinibSenolytic tyrosine-kinase inhibition — evidence-graded deep dive | Tier CPreclinical | Not scored | — | Cellular SenescenceChronic Inflammation |
| Lion's ManeA mushroom that stimulates nerve growth factor — a compelling, low-risk cognition and mood play | Tier CPreclinical | Not scored | — | Altered Intercellular CommunicationChronic Inflammation |
| Low-Dose LithiumGSK-3 and autophagy signaling — evidence-graded deep dive | Tier CPreclinical | Not scored | Limited | Disabled MacroautophagyAltered Intercellular Communication |