Mechanism, evidence tiers, dosing protocols, monitoring checklists, and personal results templates for each intervention.
Flagship glutathione restoration — human RCT backbone
Dual-precursor strategy rebuilding the glutathione triad (GSH, cysteine, glycine). Tier A human data for oxidative stres…
NAD+ precursor — sirtuin and PARP fuel
Direct NAD+ precursor bypassing NAMPT rate-limiting step. Restores NAD+ pools that decline ~50% between ages 40–60, acti…
NAD+ precursor alternative — human RCT data, manual stack substitution
Legitimate NAD+ precursor with human trial footprint. TNiC defaults to NMN for stack integration; this module covers whe…
NRF2 master regulator — 200+ cytoprotective genes
Isothiocyanate from broccoli sprouts that covalently modifies KEAP1, releasing NRF2 to drive phase-II detox, proteasome …
Epigenetic cofactor & TCA fuel — highest hallmark breadth per gram
TCA cycle intermediate and obligate cofactor for TET, JMJ, and PHD enzymes that reverse age-related DNA and histone meth…
AMPK activator — metformin-equivalent glucose outcomes without a prescription
Isoquinoline alkaloid activating AMPK with RCT-equivalent glucose control vs metformin (500 mg TID, 13-week head-to-head…
Mitophagy activator — Phase 2 muscle trial, Tier A
Gut-derived metabolite from ellagitannin polyphenols that activates mitophagy — the selective clearance of damaged mitoc…
REDUCE-IT: 25% CV event reduction — SPM resolution axis
EPA and DHA serve as precursors to specialized pro-resolving mediators (SPMs) — resolvins and protectins — that actively…
Phosphocreatine ATP buffer — Tier A for muscle and strength in aging
The best-evidenced legal amplifier of resistance training for defending against sarcopenia, with a large older-adult RCT…
Essential thyroid substrate — deficiency is quietly returning as iodized salt use falls
Essential for T3/T4 synthesis. NHANES data shows median urinary iodine in US women of childbearing age has fallen from 3…