Best Supplements for Inflammation
"Inflammaging" — chronic low-grade inflammation — predicts cardiovascular and metabolic disease and accelerates every other hallmark. These compounds have human evidence for lowering inflammatory markers (hs-CRP, IL-6) through NRF2, SPM resolution, and NF-κB pathways.
The top pick
The top-ranked pick here is Omega-3 (EPA + DHA) Tier A — Specialized Pro-resolving Mediators (SPMs). Next best-evidenced: Trans-Resveratrol and GlyNAC.
Ranked by strength of human evidence (Tier A > B > C) and mechanistic fit — computed from the compound registry, not hand-picked. Every entry links to its full evidence deep-dive with PubMed citations. Educational only, not medical advice.
- Omega-3 (EPA + DHA)Tier A
Specialized Pro-resolving Mediators (SPMs)
2–4g combined EPA+DHA daily (with fat-containing meals)AM/PM3 PMIDs - Curcumin (Curcuminoids)Tier B
NF-κB Suppression / Nrf2 Activation
1,000–1,500mg/day curcuminoids (enhanced-bioavailability form, split AM/PM with fat)AM/PM3 PMIDs The best-evidenced medicinal mushroom — PSK is an approved oncology adjunct in Japan and China
2–3 g/dayAM/PM4 PMIDs- FisetinTier B
Senolytic Clearance
100–500mg fisetin (pulse: 2 consecutive days per month preferred)AM1 PMID Brain-penetrant carnitine — Tier B for DPN, MCI, and depression with a large evidence base
500–1,000 mg TID (1,500–3,000 mg/day)AM/PM4 PMIDs
The aging mechanisms behind this goal
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What supplement lowers hs-CRP the most?
Omega-3 (EPA+DHA) has the largest cardiovascular evidence base and reliably lowers hs-CRP and IL-6, with the REDUCE-IT trial showing a 25% reduction in major cardiovascular events at 4g/day EPA. Sulforaphane and GlyNAC also reduce inflammatory markers in human trials.