Best Longevity & Anti-Aging Supplements
No supplement is proven to extend human lifespan. What the evidence supports is acting on the hallmarks of aging — genomic integrity, NAD+ metabolism, epigenetic drift, autophagy, and senescence. These compounds have the broadest, best-graded human evidence across those mechanisms.
Ranked by strength of human evidence (Tier A > B > C) and mechanistic fit — computed from the compound registry, not hand-picked. Every entry links to its full evidence deep-dive with PubMed citations. Educational only, not medical advice.
- 1
NMN
Tier ANAD+ Restoration — Tier A.
250–500mg NMN·AM·3 PMIDs - 2
Spermidine
Tier BAutophagy Induction — Tier B.
1–6mg spermidine (supplement) or dietary wheat germ·AM·2 PMIDs - 3
Ca-AKG
Tier ATCA Cycle Support — Tier A.
1–2g Ca-AKG·AM·2 PMIDs - 4
GlyNAC
Tier AGlutathione Synthesis — Tier A.
600mg glycine + 600mg NAC·AM·2 PMIDs - 5
Sulforaphane
Tier ANRF2 Activation — Tier A.
10–35mg glucoraphanin·AM·2 PMIDs - 6
Urolithin A
Tier AMitophagy Induction — Tier A.
500–1000mg urolithin A (Mitopure standardized)·AM·3 PMIDs - 7
Fisetin
Tier BSenolytic Clearance — Tier B.
100–500mg fisetin (pulse: 2 consecutive days per month preferred)·AM·1 PMID - 8
Taurine
Tier BOsmolyte / Mitochondrial Buffer — Tier B.
1–3g taurine daily·AM/PM·1 PMID
The aging mechanisms behind this goal
Want a stack built for you, not a list?
The NICO Starter Questionnaire turns your goals, lifestyle, and safety profile into a personalized, evidence-graded stack — and loads it straight into Stack Builder.
Take the NICO Starter QuestionnaireFrequently asked
Which longevity supplement has the strongest human evidence?
GlyNAC and NMN carry the strongest human RCT data (Tier A) for reversing measurable aging markers. No compound is proven to extend human lifespan — TNiC grades the marketing claim separately from the biomarker data.
How many longevity supplements should I take?
Coverage beats quantity. A small stack that spans several hallmarks (e.g. NAD+ + NRF2 + AKG) is better-evidenced than a long list of overlapping single-mechanism compounds. The NICO Starter Questionnaire builds a stack matched to your goals.