Best Longevity & Anti-Aging Supplements
No supplement is proven to extend human lifespan. What the evidence supports is acting on the hallmarks of aging — genomic integrity, NAD+ metabolism, epigenetic drift, autophagy, and senescence. These compounds have the broadest, best-graded human evidence across those mechanisms.
The top pick
The top-ranked pick here is NMN Tier A — NAD+ Restoration. Next best-evidenced: Spermidine and Ca-AKG.
Ranked by strength of human evidence (Tier A > B > C) and mechanistic fit — computed from the compound registry, not hand-picked. Every entry links to its full evidence deep-dive with PubMed citations. Educational only, not medical advice.
- FisetinTier B
Senolytic Clearance
100–500mg fisetin (pulse: 2 consecutive days per month preferred)AM1 PMID
The aging mechanisms behind this goal
Want a stack built for you, not a list?
The NICO Starter Questionnaire turns your goals, lifestyle, and safety profile into a personalized, evidence-graded stack — and loads it straight into Stack Builder.
Take the NICO Starter QuestionnaireFrequently asked
Which longevity supplement has the strongest human evidence?
GlyNAC and NMN carry the strongest human RCT data (Tier A) for reversing measurable aging markers. No compound is proven to extend human lifespan — TNiC grades the marketing claim separately from the biomarker data.
How many longevity supplements should I take?
Coverage beats quantity. A small stack that spans several hallmarks (e.g. NAD+ + NRF2 + AKG) is better-evidenced than a long list of overlapping single-mechanism compounds. The NICO Starter Questionnaire builds a stack matched to your goals.