Evidence-Based · PubMed-Cited · 2026

The evidence, compound by compound.

Deep dives on the molecules with the strongest human data in aging science — mechanism, key trials, dosing, and honest cautions. Cited throughout; affiliate links never drive the rankings.

7In-depth guides

11Compound profiles 8Head-to-head comparisons

Start with the Master Guide →Compound library

Supplement Guides

Longevity Supplement Guides

Mechanism, key human-trial data, dosing protocol, and honest cautions for each major longevity compound — structured around the 12 Hallmarks of Aging.

Deep-dive guides

Supplement-by-Supplement Coverage

Each guide covers the mechanism, key human trial data, dosing protocol, and honest cautions — structured around the 12 Hallmarks of Aging framework.

Master Guide

Best Longevity Supplements 2026

The complete ranked guide to evidence-backed longevity compounds

Start here. Our master guide ranks 12+ compounds by evidence quality, covers the Hallmarks of Aging framework, explains synergy principles, and includes honest cautions. Built on 50+ PubMed citations.

12+ compoundsTier A–D ranking50+ citations

Tier ARead guide

High Interest

NAD+ Supplement Guide

NMN vs NR, precursor hierarchy, and the NAD+ decline curve

NAD+ declines 50% by age 60. This guide compares NMN, NR, and niacin riboside as precursors — covering bioavailability data, optimal dosing windows, and why the form you choose matters for tissue distribution.

NMN vs NR vs Niacin50% decline by 60Dosing by age

Tier BRead guide

Landmark RCT

GlyNAC Supplement Guide

9 hallmarks of aging reversed in a 24-week human RCT

Sekhar et al. 2021 found GlyNAC (glycine + NAC) reversed 9 of the 12 hallmarks of aging in older adults — including a 94.6% increase in glutathione and 3.7-year epigenetic age reversal. This guide covers the evidence and the protocol.

Sekhar 2021 RCT9 hallmarks reversedGSH +94.6%

Tier ARead guide

Nature's Ozempic?

Berberine Guide

AMPK activation, metabolic evidence, and honest semaglutide comparison

Berberine activates AMPK — the cell's master energy switch — with meta-analytic evidence for HbA1c reduction (−0.72%) and LDL lowering (−0.65 mmol/L). A rigorous 7-row honest comparison with semaglutide tells you what it can and cannot do.

AMPK activationHbA1c −0.72%vs Semaglutide

Tier BRead guide

Science 2023

Taurine Longevity Guide

80% decline by age 60 and 10–12% lifespan extension in mammals

The landmark Singh et al. 2023 Science paper found taurine declines 80% by age 60 and that supplementation extended lifespan 10–12% in worms and mice, plus reversed epigenetic age in monkeys. Covers 5 longevity mechanisms and dosing protocol.

Singh 2023 Science80% decline by 60+10–12% lifespan

Tier BRead guide

NRF2 Activator

Sulforaphane & NRF2 Guide

Broccoli sprout extract, form selection, and Keap1-NRF2 mechanism

Sulforaphane from broccoli sprouts alkylates Keap1 cysteine residues, releasing NRF2 to upregulate 200+ cytoprotective genes. Covers human trial data (H. pylori, NAFLD, ASD, air pollution), form hierarchy, and the NRF2 Triad stack.

200+ NRF2 genes4 human trialsForm hierarchy

Tier BRead guide

ITP Mouse Data

Spermidine Guide

~10% ITP lifespan extension and 40% cardiovascular mortality reduction

Spermidine is one of the few OTC longevity compounds with NIA Interventions Testing Program lifespan data (~10% in female mice). The Kiechl 2018 20-year cohort found a 40% reduction in cardiovascular mortality in the highest dietary spermidine tertile. Covers EP300 inhibition mechanism, dosing, and the autophagy triad.

ITP mouse dataKiechl 2018 cohortEP300 inhibition

Tier BRead guide

Head-to-head