Evidence-Based · PubMed-Cited · 2026
The evidence, compound by compound.
Deep dives on the molecules with the strongest human data in aging science — mechanism, key trials, dosing, and honest cautions. Cited throughout; affiliate links never drive the rankings.
Reading surfaces
26linked entries
- In-depth guides727%
- Compound profiles1142%
- Head-to-head831%
Reading split · derived from the guides listed on this page
Longevity Supplement Guides
Mechanism, key human-trial data, dosing protocol, and honest cautions for each major longevity compound — structured around the 12 Hallmarks of Aging.
A better way to use this library
Move from a question to a well-framed decision.
You do not need to read the library in order. Start with the question you are trying to answer, then move from the evidence to the product context and finally to the safety questions that only your full health picture can answer.
The purpose is not to assemble the longest stack. It is to understand what a compound is being studied for, how strong that evidence is, and what information is still missing before you act.
See how TNiC grades evidence- 01
Start with the decision
Use the Master Guide for broad orientation, a compound guide for depth, or a comparison when two options are competing for the same role.
Open the Master Guide - 02
Read the evidence before the product
Check the evidence tier, study context, and stated limitations first. Product pages are a separate verification step, not proof that an outcome is guaranteed.
Review the methodology - 03
Compare the form and label
Use each guide’s study context to understand the form and amount being discussed, then compare it with the Supplement Facts label rather than relying on marketing language alone.
Use the product checklist - 04
Keep the full routine visible
Use the Stack Architect to organize your research. A complete list of medicines and supplements is the useful starting point for a clinician or pharmacist review.
Open Stack Architect
Deep-dive guides
Supplement-by-Supplement Coverage
Each guide covers the mechanism, key human trial data, dosing protocol, and honest cautions — structured around the 12 Hallmarks of Aging framework.
Harm reduction
Defense stacks for an ongoing exposure
For people who are not removing the exposure right now. Both pages state what continuing costs, grade every item on what the trials actually found, and lead with the supplements to avoid — including two that large randomised trials showed make things worse.
Cigarette smokers
Smoker Defense Stack
NAC at the dose that cut COPD exacerbations in a 1,006-patient trial, sulforaphane for NRF2, and vitamin C for a measurable depletion.
Leads with: the beta-carotene trials that found MORE lung cancer in smokers, not less.
Stimulant & methamphetamine
Stimulant Defense Stack
Oxidative, cardiac and dental mitigation for people still using, with every item graded on what the trials found rather than what the mechanism suggests.
Leads with: the serotonergic combinations that can be fatal, and the largest NAC trial — which was negative.
Head-to-head
Supplement Comparisons
Can’t decide between two options? Our structured comparison pages score each compound on 6–10 dimensions with evidence-tier ratings.
NMN vs NR
The definitive NAD+ precursor showdown
Berberine vs Metformin
AMPK activation head-to-head
Rapamycin vs Metformin
Two most-discussed longevity drugs
CoQ10 vs Ubiquinol
Oxidized vs reduced form absorption
Omega-3 vs Krill Oil
EPA+DHA delivery systems compared
Fisetin vs Quercetin
Senolytic flavonoids compared
Sulforaphane vs Curcumin
NRF2 vs NF-κB pathways
Taurine vs NMN
Two of 2023's most-studied compounds
Compound library
Individual Compound Profiles
Each compound page covers mechanism, evidence tier, hallmarks targeted, synergies, and protocol. Tightly structured for fast review.
Safety and quality checkpoint
Evidence, identity, and personal safety are three different checks.
A guide can help you understand the research. The label helps you identify the ingredient form and amount per serving. Neither replaces a conversation about your medicines, health history, or upcoming care.
Research context
Read the evidence tier, study design, and limitations before deciding what a result means.
Label and quality
Supplement Facts identifies active ingredients and amounts. Quality testing can support identity and label accuracy; it does not establish effectiveness. [1]
Personal safety
Before starting or changing a supplement, involve a qualified professional if you take medicines, are pregnant or breastfeeding, or are preparing for surgery. [2]
For label research, the NIH Dietary Supplement Label Database catalogs U.S. product-label information. [3]
Visit the Trust CenterGuide selection FAQ
Four decisions to make before you go deeper.
These answers explain how to use the content on this page; they are not a substitute for individualized medical advice.
- Where should I start if I am new to longevity supplements?
- Begin with the Master Guide for orientation, then move to the guide that matches the specific compound or comparison you are evaluating. Evidence tiers describe the strength and type of available research; they are not personal medical recommendations.
- Do these guides provide personal dosing instructions?
- No. Study sections report the form and amount used in cited research for context. They do not select an amount, schedule, or duration for an individual.
- How should I evaluate a product after reading a guide?
- Treat the research question and the product-verification question separately. Compare the label’s form and amount with the evidence context, then use the product pages to review manufacturer information and quality checks.
- When should I involve a clinician or pharmacist?
- Discuss any supplement you are considering with a qualified health professional if you take medicines, are pregnant or breastfeeding, or are preparing for surgery. Bring the complete list of medicines and supplements you use.
References. [1] NIH Office of Dietary Supplements, Dietary Supplements: What You Need to Know. [2] U.S. FDA, Mixing Medications and Dietary Supplements Can Endanger Your Health. [3] NIH Office of Dietary Supplements, Dietary Supplement Label Database.
Not sure where to start?
Take the NICO Starter Questionnaire
Answer 7 questions about your health goals, lifestyle, and budget. Get a personalized supplement stack ranked by evidence and synergy.
Start the NICO Starter QuestionnaireAfter you pick your compounds
Build your stack
The Stack Architect checks compound synergies and flags timing conflicts. Add compounds one by one and see your full protocol score.
Open Stack ArchitectUnderstand the science
Hallmarks of Aging
Every supplement recommendation on TNiC is mapped to specific hallmarks of aging. The library explains each mechanism in plain language.
Explore the library