Longevity Supplement Guides
Deep-dive guides for the compounds with the strongest evidence in aging science. Every claim is cited. Every protocol is honest about limitations. No affiliate rankings.
7
In-depth guides
11
Compound profiles
8+
Head-to-head comparisons
50+
PubMed citations
Deep-dive guides
Supplement-by-Supplement Coverage
Each guide covers the mechanism, key human trial data, dosing protocol, and honest cautions — structured around the 12 Hallmarks of Aging framework.
Best Longevity Supplements 2026
The complete ranked guide to evidence-backed longevity compounds
Start here. Our master guide ranks 12+ compounds by evidence quality, covers the Hallmarks of Aging framework, explains synergy principles, and includes honest cautions. Built on 50+ PubMed citations.
NAD+ Supplement Guide 2026
NMN vs NR, precursor hierarchy, and the NAD+ decline curve
NAD+ declines 50% by age 60. This guide compares NMN, NR, and niacin riboside as precursors — covering bioavailability data, optimal dosing windows, and why the form you choose matters for tissue distribution.
GlyNAC Supplement Guide
9 hallmarks of aging reversed in a 24-week human RCT
Sekhar et al. 2021 found GlyNAC (glycine + NAC) reversed 9 of the 12 hallmarks of aging in older adults — including a 94.6% increase in glutathione and 3.7-year epigenetic age reversal. This guide covers the evidence and the protocol.
Berberine Guide — Nature's Ozempic Reality Check
AMPK activation, metabolic evidence, and honest semaglutide comparison
Berberine activates AMPK — the cell's master energy switch — with meta-analytic evidence for HbA1c reduction (−0.72%) and LDL lowering (−0.65 mmol/L). A rigorous 7-row honest comparison with semaglutide tells you what it can and cannot do.
Taurine Longevity Guide — Singh 2023
80% decline by age 60 and 10–12% lifespan extension in mammals
The landmark Singh et al. 2023 Science paper found taurine declines 80% by age 60 and that supplementation extended lifespan 10–12% in worms and mice, plus reversed epigenetic age in monkeys. Covers 5 longevity mechanisms and dosing protocol.
Sulforaphane & NRF2 Guide
Broccoli sprout extract, form selection, and Keap1-NRF2 mechanism
Sulforaphane from broccoli sprouts alkylates Keap1 cysteine residues, releasing NRF2 to upregulate 200+ cytoprotective genes. Covers human trial data (H. pylori, NAFLD, ASD, air pollution), form hierarchy, and the NRF2 Triad stack.
Spermidine Guide — Autophagy & ITP Data
~10% ITP lifespan extension and 40% cardiovascular mortality reduction
Spermidine is one of the few OTC longevity compounds with NIA Interventions Testing Program lifespan data (~10% in female mice). The Kiechl 2018 20-year cohort found a 40% reduction in cardiovascular mortality in the highest dietary spermidine tertile. Covers EP300 inhibition mechanism, dosing, and the autophagy triad.
Head-to-head
Supplement Comparisons
Can’t decide between two options? Our structured comparison pages score each compound on 6–10 dimensions with evidence-tier ratings.
NMN vs NR
The definitive NAD+ precursor showdown
Berberine vs Metformin
AMPK activation head-to-head
Rapamycin vs Metformin
Two most-discussed longevity drugs
CoQ10 vs Ubiquinol
Oxidized vs reduced form absorption
Omega-3 vs Krill Oil
EPA+DHA delivery systems compared
Fisetin vs Quercetin
Senolytic flavonoids compared
Sulforaphane vs Curcumin
NRF2 vs NF-κB pathways
Taurine vs NMN
Two of 2023's most-studied compounds
Compound library
Individual Compound Profiles
Each compound page covers mechanism, evidence tier, hallmarks targeted, synergies, and protocol. Tightly structured for fast review.
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Hallmarks of Aging
Every supplement recommendation on TNiC is mapped to specific hallmarks of aging. The library explains each mechanism in plain language.
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