Compound Intelligence
Score every compound, mechanistically.
A transparent, rule-based instrument — evidence, effect, breadth, bioavailability, and safety scored per compound, then resolved across the twelve hallmarks of aging.
30Curated compounds
5Scoring dimensions
12Hallmarks mapped
TNiC · Cellular Intelligence
Compound Intelligence Engine
Stage supplements to score each compound mechanistically, resolve stack synergy, and watch coverage bloom across the twelve hallmarks of aging.
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Add a compound above to begin mechanistic scoring.
TNiC · COMPOUND INTELLIGENCE ENGINE — mechanistic scoring is decision-support, not medical advice.
How the engine scores
The scoring model, in full
Every compound is scored on five weighted axes, then resolved across the twelve hallmarks of aging. The model is rule-based and transparent — not generative AI. Default weights are shown below and are adjustable in the interactive engine above.
- Evidence 30% weight
- Strength of human evidence behind the compound — graded A (human RCT) through C (preclinical / mechanistic).
- Effect 22% weight
- Typical magnitude of the observed or modeled effect on aging-relevant outcomes.
- Breadth 20% weight
- How many of the twelve hallmarks of aging the compound plausibly acts on.
- Bioavailability 14% weight
- How well the compound is absorbed and reaches its target at practical oral doses.
- Safety 14% weight
- Tolerability and interaction profile at the doses actually studied.
Curated catalog
30 compounds the engine scores
This is the engine’s curated scoring dataset — a deliberately focused subset of the full evidence-graded library. Each compound links to its library deep-dive where one is published.
Tier ATier A — human RCT, strong(5)
- BerberineTier ABerberine HCl · MetabolicActs on: Deregulated nutrient sensing, Chronic inflammation
- CreatineTier ACreatine monohydrate · ErgogenicActs on: Mitochondrial dysfunction, Altered intercellular comms
- MagnesiumTier AMagnesium (glycinate/malate) · MineralActs on: Genomic instability, Mitochondrial dysfunction, Chronic inflammation
- Omega-3Tier AEPA / DHA · Essential fatty acidActs on: Chronic inflammation, Altered intercellular comms
- Vitamin D3Tier ACholecalciferol · Hormone / vitaminActs on: Chronic inflammation, Altered intercellular comms, Genomic instability
Tier BTier B — human trials, moderate(19)
- AstaxanthinTier BAstaxanthin · CarotenoidActs on: Chronic inflammation, Mitochondrial dysfunction
- Ca-AKGTier BCalcium Alpha-Ketoglutarate · TCA metaboliteActs on: Epigenetic alterations, Deregulated nutrient sensing, Chronic inflammation
- CoQ10Tier BCoenzyme Q10 / Ubiquinol · Mito cofactorActs on: Mitochondrial dysfunction, Chronic inflammation
- CurcuminTier BCurcumin · PolyphenolActs on: Chronic inflammation, Cellular senescence
- EGCGTier BEpigallocatechin gallate · CatechinActs on: Chronic inflammation, Deregulated nutrient sensing, Epigenetic alterations
- GlycineTier BGlycine · Amino acidActs on: Chronic inflammation, Loss of proteostasis
- GlyNACTier BGlycine + NAC · CombinationActs on: Mitochondrial dysfunction, Chronic inflammation, Genomic instability, Loss of proteostasis
- LactoferrinTier BLactoferrin (bovine / rhLF) · GlycoproteinActs on: Chronic inflammation, Altered intercellular comms, Mitochondrial dysfunction
- NACTier BN-Acetylcysteine · AntioxidantActs on: Chronic inflammation, Loss of proteostasis, Mitochondrial dysfunction
- NMNTier BNicotinamide Mononucleotide · NAD⁺ precursorActs on: Deregulated nutrient sensing, Mitochondrial dysfunction, Genomic instability, Epigenetic alterations
- NRTier BNicotinamide Riboside · NAD⁺ precursorActs on: Deregulated nutrient sensing, Mitochondrial dysfunction, Genomic instability
- QuercetinTier BQuercetin · FlavonoidActs on: Cellular senescence, Chronic inflammation
- R-ALATier BR-Alpha-Lipoic Acid · Redox cofactorActs on: Mitochondrial dysfunction, Chronic inflammation, Deregulated nutrient sensing
- SpermidineTier BSpermidine · PolyamineActs on: Disabled macroautophagy, Loss of proteostasis, Altered intercellular comms, Epigenetic alterations
- SulforaphaneTier BSulforaphane (glucoraphanin) · IsothiocyanateActs on: Chronic inflammation, Genomic instability, Loss of proteostasis, Epigenetic alterations
- TaurineTier BTaurine · Amino sulfonic acidActs on: Mitochondrial dysfunction, Chronic inflammation, Altered intercellular comms
- TMGTier BBetaine (Trimethylglycine) · Methyl donorActs on: Epigenetic alterations
- Urolithin ATier BUrolithin A · Mitophagy activatorActs on: Mitochondrial dysfunction, Disabled macroautophagy
- Vitamin K2Tier BMenaquinone (MK-7) · VitaminActs on: Altered intercellular comms
Tier CTier C — preclinical + mechanistic(6)
- ApigeninTier CApigenin · FlavoneActs on: Cellular senescence, Chronic inflammation, Deregulated nutrient sensing
- FisetinTier CFisetin · Senolytic flavonoidActs on: Cellular senescence, Chronic inflammation
- Lion's ManeTier CHericium erinaceus · Nootropic fungusActs on: Altered intercellular comms, Chronic inflammation
- PQQTier CPyrroloquinoline quinone · Mito cofactorActs on: Mitochondrial dysfunction
- PterostilbeneTier CPterostilbene · StilbeneActs on: Deregulated nutrient sensing, Chronic inflammation
- ResveratrolTier CResveratrol · StilbeneActs on: Deregulated nutrient sensing, Chronic inflammation, Epigenetic alterations
Curated values reflect a point-in-time evidence review and should be re-verified against current literature. Scores are a transparent, rule-based synthesis — not medical advice. Follow each compound’s library deep-dive and its PubMed links for primary sources.