Hallmark 1
Genomic Instability
When DNA repair can no longer keep pace with damage
Accumulated DNA lesions — from replication errors, radiation, and oxidative hits — overwhelm repair pathways. Unrepaired damage drives mutations, cellular dysfunction, and cancer risk.
Full deep dive + MDXDNA helix damage
My Results & Notes
Tracking prompts
- Note any family cancer history
- Track oxidative stress markers (8-OHdG if tested)
- Log sleep quality — repair peaks during deep sleep
Your stack coverage
No targeting compounds in your active stack. Build stack →
Biomarkers: 8-OHdG · γ-H2AX foci · micronuclei frequency — Log in Lab Hub
Intervention Explorer
- 1
NMN / NAD+ restoration
Tier ACompoundIn TNiC stackReplenishes NAD+ pools consumed by PARP during DNA repair. Human trials show restored NAD+ metabolites.
Impact9/10PMID: 30475480 - 2
Sulforaphane (NRF2)
Tier ACompoundIn TNiC stackActivates NQO1, GST, and other phase-II enzymes that protect DNA from oxidative adducts.
Impact8/10PMID: 38772511 - 3
Sleep optimization (7–9h)
Tier ALifestyleDNA repair enzymes peak during slow-wave sleep. Chronic restriction increases double-strand breaks.
Impact8/10 - 4
GlyNAC glutathione support
Tier ACompoundIn TNiC stackRestores glutathione — primary defense against oxidative DNA damage.
Impact7/10PMID: 33783984 - 5
Metformin
Tier BClinicalTAME trial candidate. Reduces DNA damage via AMPK and reduced ROS in preclinical models.
Impact6/10PMID: 26579537